Magenta to explore targeted gene editing to cure HIV

By The Science Advisory Board staff writers

September 3, 2020 -- Clinical-stage biotechnology company Magenta Therapeutics has joined a broad-based research effort to explore gene- and cell-based approaches to cure HIV.

The U.S. National Institutes of Health (NIH) awarded the group a five-year, $14.9 million U19 grant to advance the research into hematopoietic stem and progenitor cell (HSPC) engineering and transplantation with the goal of complete HIV-1 infection remission.

As part of the program, Magenta will optimize cell dose in animal models and determine whether HSPC transplant results in disease control. The project includes researchers studying gene editing, HIV, and stem cell transplantation at a number of premier institutions, including the University of Southern California, the University of Washington, and Harvard University.

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