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Preclinical KRAS inhibitor triggers complete responses in pancreatic tumors
A small molecule KRASG12D inhibitor has triggered complete responses in preclinical pancreatic cancer models, raising hopes that the approach can improve outcomes in the hard-to-treat tumor type.
Overexpression of estrogen receptor gene linked to breast cancer risk in older women
A first-of-its-kind mouse model of aging finds overexpression of the estrogen receptor 1 gene could increase the risk of estrogen receptor-positive breast cancer in postmenopausal women, according to research published December 1 in the
American Journal of Pathology.
Senescent neuron discovery in brains opens path for Alzheimer's drug development
Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration.
Blocking cell plasticity is essential to tackling glioblastomas: review
Therapeutics that restrain the plasticity of glioblastoma are essential to improving outcomes in patients with the lethal, hard-to-treat brain cancer, according to researchers at Australia's Flinders University.
CRISPR-Cas9 gene editing links RNA-binding protein to immunotherapy resistance
Using CRISPR-Cas9 gene editing, Swiss researchers have provided evidence that expression of an RNA-binding protein helps tumors to evade the immune system.
Cell-penetrating peptide conjugate gets chemotherapy across blood-brain barrier in mice
A macrocyclic cell-penetrating peptide conjugate has enabled a cisplatin prodrug to cross the blood-brain barrier (BBB) in mice, increasing survival rates and providing a potential pathway for treating humans with brain cancer.
Immunosuppressive pathway offers explanation for failure of TIGIT clinical trials
Albert Einstein College of Medicine scientists in a new analysis of the immunosuppressive KIR2DL5/PVR pathway provide a potential explanation for why anti-TIGIT therapies have failed in clinical trials.
Maps of genetic subclones in tumors point to new way to treat cancers
Researchers have combined whole-genome sequencing with other techniques to generate detailed quantitative maps of genetic subclones in tumors, which they contend provide a complete view of cancer that has not been previously possible.
DNA barcoding shows how breast cancer cells evade the immune system
Using DNA barcodes, scientists at Australia’s Garvan Institute of Medical Research have revealed how cancer cells can evade the immune system and render immunotherapies ineffective.
Study offers researchers more reliable way to design effective CELMoD drugs
Scripps Research scientists have discovered a key property needed for a promising new class of cancer-fighting drugs -- known as Cereblon E3 Ligase Modulating Drugs (CELMoDs) -- to work effectively as protein degraders.
Glasgow International Health Festival
January 25-26, 2023
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