Researchers develop 'wise counsel' for biological systems

By The Science Advisory Board staff writers

July 11, 2022 -- Researchers at the Max Planck Institute for Terrestrial Microbiology created Machine Learning Guided Experimental Trials for Improvement of Systems (METIS), a modular software system for optimizing biological systems.

METIS bridges the gap between machine-learning algorithms and their applications for biological systems because application and improvement of algorithms and computational procedures with lists of instructions are not easily accessible.

METIS incorporates active learning, or optimal experimental design, which uses machine-learning algorithms to interactively suggest the next set of experiments after being trained on previous results. It's a combinatorial guide for understanding complex interactions and hypothesis-driven optimization.

Led by Tobias Erb, PhD, the research team published a paper on July 5 in Nature Communications showing METIS can be used for a variety of applications, including optimization of protein production, genetic constructs, combinatorial engineering of enzyme activity, and a complex CO2 fixation metabolic cycle named crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA (CETCH).

The modular tool runs as Google Colab Python notebooks and can be used via a personal copy of the notebook on a web browser, without installation, registration, or local computational power.

A new way to account for evolution in engineered biological systems
A defining characteristic of biology is that life evolves. Traditional biological engineering views an engineered product as a final destination in the...
AACR 2021: How machine learning and artificial intelligence are transforming cancer research
The use of digital tools has been incorporated into many areas of cancer research. However, experts agree that machine learning and artificial intelligence...

Copyright © 2022 scienceboard.net


Conferences
Laboratory Products Association Annual Meeting
October 1-4
Scottsdale, Arizona United States
Cell & Gene Meeting on the Mesa
October 11-13
Carlsbad, California United States
IDWeek 2022
October 19-23
District of Columbia United States
American Society of Human Genetics Annual Meeting
October 25-29
Los Angeles, California United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter