NIH launches investigation of somatic mosaicism in human cells and tissues
The National Institutes of Health (NIH) recently launched a new program: the Common Fund’s Somatic Mosaicism Across Human Tissues (SMaHT) Network. The program, with planned awards totaling $140 million over five years, aims to enhance knowledge of how much genetic variation exists within normal human cells and tissues throughout the body. Read More
Synthego opens manufacturing facility for gene editing components
Genome engineering company Synthego on Thursday announced the opening of an 18,000 square-foot good manufacturing practice (GMP) synthesis facility for gene editing components. Read More
Next-generation statistical simulator provides benchmarking tool
UCLA researchers have developed an all-in-one, next-generation statistical simulator capable of assimilating a wide range of information to generate realistic synthetic data and provide a benchmarking tool for researchers who use advanced technologies to study diseases and potential therapies. The study, published Thursday in Nature Biotechnology, indicates that the new computer modeling, or in silico, system, can help researchers evaluate and validate computational methods. Read More
CRISPR technique cuts time to develop mouse models with any cancer-causing gene
A CRISPR-based technique has cut the time it takes to create mouse models with mutations that cause cancer, making it easier to show the effects of genetic changes linked to tumor development. Read More
Researchers pitch cytokine-antibody complex as treatment for respiratory infections
Researchers have combined a cytokine and an antibody to generate inflammatory responses against viruses while minimizing tissue damage. Read More
Alzheimer’s drug could prevent damage to the brain
Researchers showed that tiny aggregates of amyloid beta protein, a naturally occurring substance associated with Alzheimer’s disease progression, can float freely through brain tissue fluid, reaching important brain regions and disrupting local neuron functioning. The research, published Wednesday in the journal Neuron, also indicated that a newly-approved Alzheimer’s disease treatment could neutralize these tiny aggregates, also known as protofibrils or oligomers. Read More
A closer look at long COVID symptoms
Patients with persistent neurological symptoms after SARS-CoV-2 infections were intensively studied and found to have autonomic dysfunction and differences in their immune cell profiles. The findings, published last Friday in Neurology: Neuroimmunology & Neuroinflammation, may help explain lingering long-COVID neurological symptoms, and lead to better diagnoses and treatments. Read More
Discovery of markers on long-lasting immune cells lights way to more durable vaccine responses
Researchers have identified surface markers on cells that continue producing antibodies for a long time, pointing to a way to improve the duration of response to vaccines. Read More
Pfizer, Thermo Fisher Scientific collaborate to broaden access to NGS testing in underserved countries
Pfizer and Thermo Fisher Scientific on Tuesday announced they have entered into a collaboration agreement to help increase local access to next-generation sequencing (NGS)-based testing for lung and breast cancer patients in more than 30 countries. Read More
An unprecedented view of gene regulation
Massachusetts Institute of Technology (MIT) engineers have developed a technique to analyze the organization of the genome at a resolution 100 times higher than was previously possible. Read More
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