DNA-based ‘nanotransporters’ deliver precise concentrations of drugs
Canadian researchers have designed and validated a new class of DNA-based drug transporters that are 20,000 times smaller than a human hair, which they contend may improve how cancers and other diseases are treated. Read More
Study provides path for overcoming blood-tumor barrier in treating medulloblastoma
Scientists at Toronto's Hospital for Sick Children have identified a way to reduce the impact of the blood-tumor barrier for treating medulloblastoma, the most common malignant pediatric brain tumor. Read More
Enzyme shown to restore cell volume after exposure to external stressors
Researchers at the University of Pittsburgh and Carnegie Mellon University have shown that with-no-lysine (WNK) kinases activate a "switch" to restore cell volume after exposure to an external stressor, such as high levels of salt or sugar. Read More
New computational method maps architecture of human tissues in unprecedented detail
Weill Cornell Medicine researchers have developed a new computational method to map the architecture of human tissues in unprecedented detail, with the potential to accelerate studies on organ-scale cellular interactions and enable powerful new diagnostic strategies for an array of diseases. Read More
Genetic timestamping model reveals lifespan of cells behind vaccine-induced immunity
A genetic timestamping mouse model has shown the rate at which antibody-producing cells accumulate and disappear after vaccination, which could ultimately allow researchers to be able to increase the longevity of immunity from vaccines. Read More
Programmable RNA-sensing technology enables manipulation of specific cell type
Researchers have developed a programmable RNA-sensing technology that triggers the production of a payload protein when it encounters specific cell types, with potential applications in diagnostics and therapeutics. Read More
Academic CDMOs, like commercial ones, play critical role in CGT sector
The cell and gene therapy (CGT) industry is growing and academic contract development and manufacturing organizations (CDMOs) -- like their larger commercial counterparts -- are playing a critical role in the ecosystem, according to Stuart Curbishley, PhD, head of business and process development at the University of Birmingham’s Advanced Therapies Facility. Read More
Challenge to textbook model of GPCR-mediated signaling opens door to new therapies
University of California, San Diego researchers have challenged the textbook model of how G protein-coupled receptors (GPCRs) mediate signaling in a study that could change how drugs against widely pursued targets are developed, including multiple forms of cancer. Read More
Gene overexpression may protect against Alzheimer’s disease: study
Scientists at the University of Colorado Anschutz Medical Campus have discovered the overexpression of a gene tied to cell division and the structure and function of neurons may prevent and protect against cognitive decline in both mice and humans with Alzheimer’s disease. Read More
EGFR-targeting cell penetrating peptide treats triple-negative breast cancer in mice
A cell penetrating peptide designed to mimic an epidermal growth factor receptor (EGFR) binding domain has induced tumor regression in mice, opening up a new avenue of research into the treatment of triple-negative breast cancer. Read More
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