Study finds tuberculosis vaccines cost-effective in lower-income countries
Harvard University researchers and collaborators conducted a modeling study that showed tuberculosis vaccination could be cost-effective in 73 of 105 low- and middle-income countries. The results, published on January 24 in PLOS Medicine, also predicted $474 billion in vaccine-related benefits by 2050. Read More
Abnormal 12-hour cyclic activity found in schizophrenic brains
University of Pittsburgh researchers have found the first evidence of 12-hour cycles of gene activity, called ultradian rhythms, in the human brain. The National Institutes of Health-funded study, published in PLOS Biology on January 24, also reveals that some ultradian rhythms are missing or altered in the postmortem brains of patients with schizophrenia. Read More
DNA tests show that mystery inflammatory syndrome may not be so rare
A rare syndrome that was first described in 2020 affects more than 15,000 adults ages 50 and older, according to an estimate published on Tuesday in JAMA Network. Read More
Predicting metabolic bone disease in infants
Chinese researchers and their collaborators have developed an artificial neural network model that can help predict metabolic bone disease in infants in both the prenatal and postnatal periods. The study, published on January 23 in JAMA Network Open, sought to detect the pivotal factors associated with MBD in each period. Read More
Peptide suppresses inflammation in mice, spurs work to develop 1st targeted lung injury therapy
A peptide has suppressed acute lung injury (ALI) in mice harmed by bacterial infection, revealing a path to developing the first targeted medical therapy for the condition. Read More
DNA sequencing method offers peek into genomic black box
University of Cambridge researchers have outlined a new DNA sequencing method that detects where and how small molecule drugs interact with a targeted genome. The research, published on January 23 in Nature Biotechnology, allows precise mapping of drug-genome binding sites, potentially enabling the development of more effective medications. Read More
mRNA COVID-19 booster rates low among immunocompromised
Researchers have found low adherence to the Centers for Disease Control and Prevention's mRNA monovalent COVID-19 booster recommendations among immunocompromised individuals. Read More
Improved tool for long-read RNA sequencing unveiled
Researchers at Children's Hospital of Philadelphia have developed a new, more accurate computational tool for long-read RNA sequencing. The tool, called Error Statistics Promoted Evaluator of Splice Site Options, described Friday in Science Advances, may allow for better diagnosis of rare genetic diseases caused by disrupted RNA and the discovery of potential therapeutic targets in disease. Read More
Personalized bile duct cancer treatment improves prognosis
University College London (UCL) researchers and others involved in an international multicenter trial found that a new personalized cancer treatment can significantly improve prognoses for certain bile duct cancer patients. The results of the Phase II open label clinical trial, published January 19 in the New England Journal of Medicine, found that patients otherwise facing end-of-life care survived for up to two years when treated with the drug futibatinib. Read More
'Living medicine' for drug-resistant lung infections
Researchers have engineered a bacterium that serves as a “living medicine” to treat antibiotic-resistant lung infections -- the leading cause of hospital mortality. The research, published January 19 in the journal Nature Biotechnology and supported through CaixaResearch Health, focused on the antibiotic-resistant bacterium Pseudomonas aeruginosa, a common source of difficult-to-treat hospital infections. Read More
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