Overexpression of estrogen receptor gene linked to breast cancer risk in older women
A first-of-its-kind mouse model of aging finds overexpression of the estrogen receptor 1 gene could increase the risk of estrogen receptor-positive breast cancer in postmenopausal women, according to research published December 1 in the American Journal of Pathology. Read More
Sound waves sort extracellular vesicles to enable liquid biopsies, regenerative therapies
Duke University engineers have used sound waves to separate small extracellular vesicles from biofluids, laying the groundwork for the development of next-generation liquid biopsies and regenerative therapies. Read More
Senescent neuron discovery in brains opens path for Alzheimer's drug development
Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration. Read More
Single-cell fetal brain profiling uncovers potential ways to treat pediatric tumors
A multinational team of scientists has used single-cell profiling of freshly isolated human fetal tissue to reveal a reference map of the cell states of the most common malignant childhood brain cancer. Read More
Blocking cell plasticity is essential to tackling glioblastomas: review
Therapeutics that restrain the plasticity of glioblastoma are essential to improving outcomes in patients with the lethal, hard-to-treat brain cancer, according to researchers at Australia's Flinders University. Read More
Cryo-EM reveals 3D structure of inflammasomes implicated in multiple diseases
Using cryo-electron microscopy (cryo-EM), researchers from Harvard Medical School and Peking University have generated 3D images of the inflammasome in its active state for the first time, enabling scientists to view a structure linked to multiple diseases in near-atomic resolution. Read More
CRISPR pioneer finds new genome-editing systems in analysis of viral genomes
The discovery of CRISPR-Cas enzymes in bacteriophages has revealed a new source of potential tools for editing the genome. Read More
Multivalent mRNA vaccine protects animals against variety of influenza strains
A multivalent mRNA vaccine has protected animals against a variety of influenza strains, suggesting the candidate could play a role in mitigating the threat of seasonal and pandemic flu. Read More
Scientists uncover viral vectors that cross the blood-brain barrier
Using a "directed-evolution" strategy in mice and macaques, scientists at the Broad Institute of Massachusetts Institute of Technology and Harvard have identified adeno-associated viruses that cross the blood-brain barrier, advancing efforts to develop neurological disease gene therapies. Read More
Researchers expand CRISPR-based genome engineering toolbox
North Carolina State University researchers have expanded the CRISPR-based gene editing toolbox with new DNA integrases that have potential applications for biotechnology and therapeutics. Read More
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