Beckman Coulter, Sciex collaborate on high-throughput screening workflows
February 27, 2023 -- Life science analytical technologies company Sciex on Monday announced a collaboration with Beckman Coulter Life Sciences to provide comprehensive workflows for high-throughput screening; high-throughput absorption, distribution, metabolism, and excretion (HT-ADME); and synthetic biology studies. Read More
Data-driven modeling predicts hydrogel properties to accelerate biomedical research
January 31, 2023 -- Researchers have developed a data-driven modeling approach for predicting the properties of injected hydrogel blocks. Read More
Shared genetic markers linked with substance use disorders
March 24, 2023 -- By combing through genomic data from more than one million people, scientists have identified genes commonly inherited across addiction disorders, regardless of the substance being used. Read More
RNA-seq analysis links protein to spread of pancreatic cancer, reveals potential drug target
March 23, 2023 -- An analysis of 400 pancreatic cancer tumor samples has linked a protein that controls RNA processing to the formation of metastases, suggesting that it may be possible to delay the spread of the cancer. Read More
A*STAR partners with startup to create diabetes cell therapies tailored to Asian patients
March 22, 2023 -- BetaLife has acquired the rights to human induced pluripotent stem cell (iPSC) technology from Singapore’s Agency for Science, Technology, and Research (A*STAR) for use in the treatment of diabetes. Read More
CRISPR/Cas9 mouse model reveals cellular function changes that drive rare disease
March 21, 2023 -- A CRISPR/Cas9 mouse model has shown how mutations that cause a rare disease affect cellular function, shedding light on how to monitor and treat the condition in the process. Read More
Thermo Fisher Scientific opens cell therapy facility at University of California, San Francisco
March 27, 2023 -- Thermo Fisher Scientific and the University of California, San Francisco (UCSF) said Monday that they will develop cell therapies for difficult-to-treat conditions, including cancers, rare diseases, and other illnesses. Read More
Swiss spatial biology firm Lunaphore raises 40 million Swiss francs
March 24, 2023 -- Lausanne, Switzerland-based Lunaphore said Thursday it has closed 40 million Swiss francs (CHF) ($43.5 million) in a Series D1 financing. Read More
Rapid nirmatrelvir treatment may reduce long COVID risk
March 24, 2023 -- A study of people with SARS-CoV-2 infection who had at least one risk factor for progression to severe disease found that treatment with nirmatrelvir within five days of a positive SARS-CoV-2 test result was associated with reduced risk of post−COVID-19 condition, known as long COVID. The findings, published Thursday in JAMA Internal Medicine, held true across the risk spectrum in this cohort, regardless of vaccination status and history of prior infection. Read More
Simpler, cheaper screening method developed to democratize COVID-19 drug discovery
March 15, 2023 -- An alternative method for finding single-chain antibodies has yielded COVID-19 drug candidates that may be effective against variants of concern. Read More
Clinical investigators need to be wary of confounding and bias in real-world studies; here is what to look for and how to address it
March 17, 2023 -- Clinical investigators use real-world data (RWD) in randomized trials and observational studies to produce real-world evidence (RWE) used to assess the safety and efficacy of an intervention and to inform product development, regulatory approval, and post-market surveillance efforts. Read More
HER2-targeting nanoparticles eradicate tumors in mice in ‘hit and run’ attack
March 17, 2023 -- A nanoparticle loaded with HER2-targeting antibody fragments and cytotoxic payloads performs a “hit and run” attack on gastric cancers in mice, eradicating the tumors while being safely cleared from the body via the kidneys to minimize toxicity. Read More
Sophia Genetics partnering with Agilent Technologies to offer cancer analysis solution
March 15, 2023 -- Healthcare software firm Sophia Genetics said on Tuesday that it is partnering with Agilent Technologies to offer a comprehensive solution for cancer analysis. Read More
Correlation of enzyme to survival reveals potential target for metastatic solid tumors
March 10, 2023 -- The enzyme lysyl hydroxylase 1 (LH1) promotes the migration and metastasis of solid tumor cells and is associated with shorter survival, according to a recent study published in Molecular Cancer. Read More
Implication of nervous system in anaphylaxis opens ways to treat severe allergic reactions
March 20, 2023 -- Heat-sensing neurons are key contributors to severe allergic shock reactions, according to a study in mice that points to ways to reverse life-threatening symptoms. Read More
Nasal antibody modulates inflammatory response in COVID-19 patients in small clinical trial
March 9, 2023 -- A nasally administered monoclonal antibody modulated inflammatory responses in COVID-19 patients in a small clinical trial. Read More
At SLAS 2023, BioAuxilium Research announces expansion of TR-FRET technology portfolio
March 1, 2023 -- BioAuxilium Research this week announced the expansion of its no-wash Thunder time-resolved Förster resonance energy transfer (TR-FRET) technology portfolio at the annual Society for Laboratory Automation and Screening (SLAS) International Conference and Exhibition in San Diego. Read More
Machine learning finds potential brain cancer drug targets in multi-omics dataset
February 2, 2023 -- Researchers have applied machine learning to a multi-omics dataset to identify the kinases that drive tumor growth and drug resistance in certain types of brain tumor. Read More
Scientists create cell atlas of developing human lung
December 9, 2022 -- Researchers from the Wellcome Sanger Institute, EMBL’s European Bioinformatics Institute, the Gordone Institute at the University of Cambridge, and collaborators have created a spatiotemporal cell atlas of the developing human lung. From the mapping, they have identified 144 cell states in the early stages of life and their interactions in new detail. Read More
Senescent neuron discovery in brains opens path for Alzheimer's drug development
December 2, 2022 -- Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration. Read More
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