Innovative approach keeps cells alive during RNA extraction
Scientists at the Swiss Federal Institute of Technology Lausanne (EPFL) and ETH Zurich have jointly developed an innovative single-cell transcriptome profiling approach, called Live-seq, that keeps cells alive during RNA extraction for further study while also being minimally invasive. Read More
NIH awards $10.6M grant to create atlas of aging cells
The National Institutes of Health (NIH) has awarded a $10.6 million grant as part of the Cellular Senescence Network program, which aims to create a comprehensive atlas of how and where aging cells accumulate in tissues to advance potential treatments for age-related diseases. Read More
Researchers further understanding of microglia, immune cells that reside in the brain
Harvard University and Broad Institute of Massachusetts Institute of Technology scientists have furthered the understanding of microglia, showing how these immune cells are prompted to change their state to adapt to different areas of the brain. Read More
Molecular, genetic mechanisms of microglia predispose individuals to Alzheimer's: study
Mount Sinai researchers contend they have achieved an “unprecedented” understanding of the genetic and molecular mechanisms in human microglia, immune cells that reside in the brain, providing insights into how they contribute to the development and progression of Alzheimer’s disease. Read More
Map of brain changes in Alzheimer’s reveals potential target cell for drug therapies
A National Institute of Aging-backed project has released large-scale cellular and molecular information taken from more than 1.2 million neurons and other brain cells. Read More
AIDS 2022 research sheds new light on HIV cells
New research presented at the AIDS 2022 conference shows the HIV-infected memory CD4+ T-cell reservoir is a distinctive cell population that may be uniquely susceptible to specific targeted therapies. Read More
Single-cell analyses shed light on drug resistance of melanoma brain metastases
Using single-cell genetic analyses of frozen brain samples, Columbia University researchers have uncovered evidence of how melanoma brain metastases evade current treatments. Read More
Single-cell sequencing finds subset of CAR T cells that drive anticancer effects
A small subset of the CAR T cells prepared for therapy produce most of the anticancer activity, suggesting it may be possible to improve the treatment, according to a study published in the journal Cancer Discovery. Read More
Global consortium creates 'largest' zebrafish genetic atlas to support human disease research
An international consortium of 27 laboratories called DANIO-CODE has created an atlas of genetic data on zebrafish to support research into conditions including cancer, heart disease, and neurodegeneration. Read More
Single DNA strand cuts achieve safety and efficacy edge over CRISPR-Cas9 in fruit flies
CRISPR-Cas9 variants known as “nickases” that target a single DNA strand may increase the success rate of gene editing and reduce the risk of off-target mutations, according to a paper published in the journal Science Advances. Read More
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