Map of brain changes in Alzheimer’s reveals potential target cell for drug therapies
A National Institute of Aging-backed project has released large-scale cellular and molecular information taken from more than 1.2 million neurons and other brain cells. Read More
RNA molecules identified as potential ‘common driver’ of cancer progression
Moffitt Cancer Center researchers have challenged the widely held view that protein structure and function are the key drivers of cancer development. Their study found competitive endogenous RNA drive melanoma growth and metastasis by blocking the antitumor activity of other molecules. Read More
Ribosome profiling expands pool of potentially protein-coding regions of DNA
Using ribosome profiling, researchers from 20 institutions worldwide have identified more than 7,200 previously unrecognized gene segments of the human genome that may code for new proteins. Read More
Large DNA insertions in CRISPR-edited cells could increase cancer risk: study
CRISPR-Cas9 can cause large rearrangements of DNA through retrotransposition to theoretically trigger tumor development, according to a paper published in Nature Communications. Read More
Beta cell gene deletion stops type 1 diabetes in mice, suggesting new way to prevent disease
Deleting a proinflammatory gene in the beta cells of pre-diabetic mice stops the development of type 1 diabetes, pointing to a potential way to prevent the condition, according to a study published on June 28 in the journal Cell Reports. Read More
Tokyo team challenges 10x Genomics with new single-cell RNA sequencing method
Researchers have developed a single-cell RNA sequencing method that is designed to tackle the cell sampling bias of existing techniques and deliver high-precision data, according to a paper published on June 27 in Nature’s Communications Biology journal. Read More
Biotech innovator recounts decades-long journey to create drug discovery technology
Dr. Stan Crooke, PhD, founder, chairman, and chief executive officer of RNA therapy company Ionis Pharmaceuticals, pioneered development of the antisense technology platform and created one of the largest, most advanced pipelines in the biotech industry. Crooke shared his story in an interview with ScienceBoard.net. Read More
Cellular map of tissues created by combining sequencing techniques
Researchers have described an approach to combine single-cell sequencing experiments with spatial transcriptomics to create maps of tissues according to cell type, according to new research published on March 21 in the journal Nature Biotechnology. Read More
Endosomal pH drives stemness in glioblastoma
A group of researchers has shown that endosomal pH drives stemness in glioblastoma. The group discovered that endosomal Na+/H+ exchanger isoform 9 is a novel driver of stem cell-like characteristics -- or stemness -- in glioblastoma by stabilizing multiple receptor tyrosine kinases, according to a recent paper published in PNAS Nexus. Read More
'Roadmap' reveals how cells transform during mouse embryonic development
Mapping how complex animals develop from a single cell is a key area of study, but it remains a significant challenge. Now, research published in Nature Genetics on March 14, has laid out the molecular changes that control how cells transform during mouse embryonic development. The resulting roadmap identifies potential links between cell types to help understand the paths they take toward specialization. Read More
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