Protein crystallography links rigid antibody hinges to increased anticancer activity
Researchers at the University of Southampton have gained new insight into the key properties of an antibody needed to fight off cancer using protein crystallography, revealing that the flexibility of the hinge between the arms of IgG2 antibodies affects the anticancer effects triggered by the molecules. Read More
EMBL partners with DeepMind to predict 3D structure of human proteins
Google Health's DeepMind announced a partnership with the European Molecular Biology Laboratory (EMBL) to offer the scientific community open access to the most comprehensive database developed to date of predicted 3D protein structures. Read More
Future of small-molecule drugs lies in oral formulations
The way forward for small-molecule drug manufacturers is through orally administered products, according to Spiro Rombotis, president and CEO of Cyclacel, who recently spoke with ScienceBoard.net. Read More
How one mammalian DNA polymerase challenges the central dogma of biology
New research demonstrates how an unusual mammalian DNA polymerase can facilitate the conversion of RNA into DNA -- the opposite of normal polymerase function. The data, published in Science Advances on June 11, could challenge the central dogma of molecular biology that states that DNA makes RNA, which in turn makes proteins. Read More
Scientists show how SARS-CoV-2 wreaks havoc in lungs
Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 envelope protein in a study published June 8 in Nature Communications. The model shows how the virus interacts with lung proteins, helping to explain how SARS-CoV-2 causes extensive lung damage. Read More
How the South African SARS-CoV-2 variant evades antibodies
Computer modeling has demonstrated that one of the three mutations of the South African SARS-CoV-2 variant reduces its ability to bind to human cells. The results, published recently in the Journal of Medicinal Chemistry, also suggest that the mutation may help it escape some therapeutic antibodies. Read More
New tool sheds light on transient protein interactions in cells
Researchers have developed a novel chemical tool for elucidating protein interaction networks within cells. The technique, details of which were published in Molecular Cell on April 23, allows for the visualization of protein-protein interactions. Read More
Naturally occurring molecule helps SARS-CoV-2 evade neutralizing antibodies
Researchers have identified naturally occurring molecules that are created from the breakdown of hemoglobin and block the binding of a subset of human antibodies to SARS-CoV-2. The discovery, published in Science Advances on April 22, may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus. Read More
X-ray crystallography identifies drugs to be repurposed for COVID-19
A new large-scale study indicates x-ray crystallography can be used to find drugs that could be repurposed to target the SARS-CoV-2 main protease. In addition to identifying 37 potential drug candidates, the study, published in Science on April 2, revealed a new binding site on the SARS-CoV-2 main protease to which drugs can bind. Read More
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