Immunology
CRISPR reveals interconnected map of immune feedback loops, regulatory networks
The disruption of thousands of genes using CRISPR-Cas9 gene editing has revealed a map of how human immune cells function. The resulting map could reveal the collections of genes that need to function properly to prevent immune diseases. Read More
Researchers capture images of antibody attacking neuron receptor
U.S. and German researchers have captured the first images of an antibody attacking a nerve cell surface receptor using cryo-electron microscopy, a technique that freezes proteins in place to get high-resolution microscopic images, according to a study published in Cell. Read More
Protein crystallography links rigid antibody hinges to increased anticancer activity
Researchers at the University of Southampton have gained new insight into the key properties of an antibody needed to fight off cancer using protein crystallography, revealing that the flexibility of the hinge between the arms of IgG2 antibodies affects the anticancer effects triggered by the molecules. Read More
Single-cell sequencing finds subset of CAR T cells that drive anticancer effects
A small subset of the CAR T cells prepared for therapy produce most of the anticancer activity, suggesting it may be possible to improve the treatment, according to a study published in the journal Cancer Discovery. Read More
NIH-funded research yields promising results for potential universal flu vaccines
A study funded by the National Institutes of Health (NIH) has shown that a new universal flu vaccine offers broad protection against different strains and subtypes of influenza A virus infections. Read More
Machine learning model opens door to real-time detection of cell therapy contamination
Researchers at the Massachusetts Institute of Technology’s Singapore site have developed a new way to detect adventitious microbial contamination in mesenchymal stromal cell cultures. By using machine learning to predict if a culture is contaminated in near real-time, the approach could enable testing to take place during the production of cell therapy products. Read More
Beta cell gene deletion stops type 1 diabetes in mice, suggesting new way to prevent disease
Deleting a proinflammatory gene in the beta cells of pre-diabetic mice stops the development of type 1 diabetes, pointing to a potential way to prevent the condition, according to a study published on June 28 in the journal Cell Reports. Read More
Life sciences industry’s search for talent is becoming more challenging: study
While more professionals are engaged in life sciences research in the U.S. and a record number of people are graduating in the biological and biomedical sciences, the ability of employers to find life sciences research talent is proving extremely difficult, according to a new report from CBRE. Read More
Manufacturing partnerships support high quality cell therapies
Chimeric Therapeutics, Ncardia, and Novartis are some of the companies that have decided to partner to make complex manufacturing processes more efficient for novel therapies, according to Cell and Gene Therapy Business Outlook, a sister publication of ScienceBoard. Read More
MASTER technology could transform CAR T-cell therapy
A new technology that helps CAR T cells attack cancer cells more aggressively than conventional methods has been published by researchers from North Carolina. Called multifunctional alginate scaffold for T-cell engineering and release (MASTER), the technology was described in a paper published on March 24 in Nature Biotechnology. Read More
Conferences
Laboratory Products Association Annual Meeting
October 1-4
Scottsdale, Arizona United States
Cell & Gene Meeting on the Mesa
October 11-13
Carlsbad, California United States
IDWeek 2022
October 19-23
District of Columbia United States
American Society of Human Genetics Annual Meeting
October 25-29
Los Angeles, California United States
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