Immunology
Antiviral-antibody combination improves influenza outcomes in mice
Researchers at McMaster University found in a mouse study that combining a class of well-known antiviral drugs and neutralizing antibodies was more effective than either approach alone, which they contend could be used to treat seasonal influenza and help prevent the next flu pandemic. Read More
Hormone restrains growth of liver tumors in mice, offers therapeutic targets
University of Michigan researchers have identified in a mouse study a hormone -- neuregulin 4 -- that serves as a checkpoint for the progression of nonalcoholic steatohepatitis and appears to have potential as a treatment for hepatocellular carcinoma, the most common type of primary liver cancer. Read More
Synthesis breakthrough opens door to development of natural product as cancer therapy
Princeton University scientists have halved the number of steps needed to synthesize pleurotin, setting the stage for work to realize the anticancer and antibiotic potential of the molecule. Read More
First full map of immune system connections unlocks drug discovery opportunities
Researchers have created the first full map of immune system connections showing how immune cells communicate, pointing to ways to modulate the pathways to treat cancer and infectious diseases. Read More
Adjuvanted liposomal vaccine protects baby mice from RSV, looks promising for human newborns
After a more than 50-year wait, a vaccine to protect infants from respiratory syncytial virus (RSV) -- the leading global cause of death in children under age five -- could finally become a reality. A single dose of an adjuvanted liposomal vaccine formulation has induced protection against RSV infection in baby mice. Read More
Researchers identify T cells that protect against ischemic stroke in mice
University of Pittsburgh neurologists and immunologists have identified a subset of CD8+ regulatory-like T cells (CD8+TRLs) that provide fast-acting and lasting protection against ischemic stroke in mice, offering a potentially novel immunotherapy for stroke in humans. Read More
Lipid in cell membrane of gut bacterium linked to effects on immunity
Researchers have found a lipid in the cell membrane of Akkermansia muciniphila that is responsible for the effect of a gut-resident bacterium on immune processes, with the potential to develop drugs that fight disease by piggybacking on the molecular mechanism. Read More
CRISPR-based study identifies lung proteins that promote, protect against SARS-CoV-2 infections
A study led by University of California, Berkeley researchers has identified specific proteins within the human body that can either promote SARS-CoV-2 infections or protect against them, a discovery they contend could lead to new antiviral therapies. Read More
3D imaging reveals picture of T-cell activity to unlock solid tumor opportunity
Researchers have used imaging and transcriptomics to identify T cells with potent serial killing capacity in a push to expand use of the immunotherapies to solid tumors. Read More
Research shows heart-damaging route of SARS-CoV-2 spike protein
Researchers have demonstrated that the spike protein from the SARS-CoV-2 virus can lead to heart muscle injury through the inflammation process, according to preliminary research to be presented this week at the American Heart Association’s 2022 Basic Cardiovascular Sciences Scientific Sessions. Read More
Conferences
Glasgow International Health Festival
August 24-27
Glasgow, Glasgow City United Kingdom
Pharma Competitive Intelligence Conference and Exhibition
September 21-22
Newark, New Jersey United States
BioProcess International (BPI) Conference
September 27-30
Boston, Massachusetts United States
Laboratory Products Association Annual Meeting
October 1-4
Scottsdale, Arizona United States
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