Antiviral-antibody combination improves influenza outcomes in mice Researchers at McMaster University found in a mouse study that combining a class of well-known antiviral drugs and neutralizing antibodies was more effective than either approach alone, which they contend could be used to treat seasonal influenza and help prevent the next flu pandemic.Read More
Hormone restrains growth of liver tumors in mice, offers therapeutic targets University of Michigan researchers have identified in a mouse study a hormone -- neuregulin 4 -- that serves as a checkpoint for the progression of nonalcoholic steatohepatitis and appears to have potential as a treatment for hepatocellular carcinoma, the most common type of primary liver cancer.Read More
Adjuvanted liposomal vaccine protects baby mice from RSV, looks promising for human newborns After a more than 50-year wait, a vaccine to protect infants from respiratory syncytial virus (RSV) -- the leading global cause of death in children under age five -- could finally become a reality. A single dose of an adjuvanted liposomal vaccine formulation has induced protection against RSV infection in baby mice.Read More
Researchers identify T cells that protect against ischemic stroke in mice University of Pittsburgh neurologists and immunologists have identified a subset of CD8+ regulatory-like T cells (CD8+TRLs) that provide fast-acting and lasting protection against ischemic stroke in mice, offering a potentially novel immunotherapy for stroke in humans.Read More
Lipid in cell membrane of gut bacterium linked to effects on immunity Researchers have found a lipid in the cell membrane of Akkermansia muciniphila that is responsible for the effect of a gut-resident bacterium on immune processes, with the potential to develop drugs that fight disease by piggybacking on the molecular mechanism.Read More
Research shows heart-damaging route of SARS-CoV-2 spike protein Researchers have demonstrated that the spike protein from the SARS-CoV-2 virus can lead to heart muscle injury through the inflammation process, according to preliminary research to be presented this week at the American Heart Association’s 2022 Basic Cardiovascular Sciences Scientific Sessions.Read More