Large-scale WGS of thousands of cancers find previously unreported mutational signatures
Large-scale whole-genome sequencing (WGS) of thousands of cancers has found previously unreported mutational signatures, including tumor-specific rare signatures, according to research published on April 21 in Science. Read More
Berkeley Lab offers CRAGE kit for genome engineering
Lawrence Berkeley National Laboratory (Berkeley Lab) is offering a trial kit for its chassis-independent, recombinase-assisted, genome engineering (CRAGE) tool. Read More
Endosomal pH drives stemness in glioblastoma
A group of researchers has shown that endosomal pH drives stemness in glioblastoma. The group discovered that endosomal Na+/H+ exchanger isoform 9 is a novel driver of stem cell-like characteristics -- or stemness -- in glioblastoma by stabilizing multiple receptor tyrosine kinases, according to a recent paper published in PNAS Nexus. Read More
Funding for cell and gene therapies exceeded $70B in 2021
Total funding from all sources for cell and gene therapy companies totaled $70.8 billion last year, according to the recent “Cell and Gene Therapy Deals: Financings, Partnering, M&A, Technology Transfers, IPOs, and Other Developments” report published by Kalorama Information, a sister company of ScienceBoard. Read More
Nucleosomes dictate the histone code
The histone code concept needs to be redefined at the nucleosomal level, according to Michael-Christopher Keogh, PhD, chief scientific officer of EpiCypher. During a live webinar, Keogh shared information about the tools that are required to critically re-evaluate the genomic distribution and regulatory function(s) of histone post-translational modification (PTMs). Read More
Applied DNA and EvviVax publish data for potential cancer immunotherapy
Applied DNA Sciences and EvviVax have published a manuscript detailing a preclinical study showing that LinearDNA vaccines used for cancer immunotherapy produced a strong immune and specific antitumoral response in preclinical mouse models. The study investigated the use of the LinearDNA platform to produce DNA vaccines targeting either tumor-associated antigens (TAAs) or tumor-specific antigens (TSAs, or tumor neoantigens). Read More
SPT Labtech launches 2 new liquid handling platforms at SLAS 2022
BOSTON - SPT Labtech unveiled its new firefly liquid handling platform for next-generation sequencing library preparation and the apricot DC1, a 4-in-1 automated liquid handling platform, at the Society for Laboratory Automation and Screening (SLAS) 2022 International Conference and Expo. Read More
Atlas finds hundreds of genes that control the brain's shape
The shapes of our brains are heavily influenced by our genes, although the precise nature of this complex relationship is difficult to pin down. Now, a study published on February 3 in Science has used a genetics-based atlas of the cerebral cortex to identify hundreds of new gene variants that are linked to growth of specific regions. Read More
New genetic benchmark improves the diagnosis of several diseases
The Genome in a Bottle consortium has documented a benchmark set of challenging, medically relevant autosomal genes with a haplotype-resolved, whole-genome assembly that are associated with several diseases. The details of the research were published in Nature Biotechnology on February 7. Read More
EpiCypher, New England Biolabs codevelop Cut&Run library prep kit
EpiCypher has entered into a partnership with New England Biolabs (NEB) to codevelop a first-in-class library prep kit specifically optimized for best performance with EpiCypher’s CUTANA Cut&Run epigenomic assays. Read More
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