Funding for cell and gene therapies exceeded $70B in 2021
Total funding from all sources for cell and gene therapy companies totaled $70.8 billion last year, according to the recent “Cell and Gene Therapy Deals: Financings, Partnering, M&A, Technology Transfers, IPOs, and Other Developments” report published by Kalorama Information, a sister company of ScienceBoard. Read More
Scientists improve ADC development with mix of experimental, computational tools
BOSTON -- Greg Thurber, PhD, professor at the University of Michigan explained how his lab is jointly using both experimental animal models and computational models to improve the overall speed and efficiency of drug development of antibody-drug conjugates (ADCs) to get more of the agents on the market. Thurber presented in a scientific session at the Society for Laboratory Automation and Screening (SLAS) 2022 International Conference and Expo. Read More
Step toward broader treatment for Duchenne muscular dystrophy
Current therapies to treat Duchenne muscular dystrophy, a genetic muscle-wasting disease, only work in a small proportion of people with the condition. Research published on February 21 in the Proceedings of the National Academy of Science provides a proof of concept for developing a therapy that could work for almost half of the people affected. Read More
Nucleosomes dictate the histone code
The histone code concept needs to be redefined at the nucleosomal level, according to Michael-Christopher Keogh, PhD, chief scientific officer of EpiCypher. During a live webinar, Keogh shared information about the tools that are required to critically re-evaluate the genomic distribution and regulatory function(s) of histone post-translational modification (PTMs). Read More
How one company is helping make complex medicines safer
Often, the most dangerous things in life are things that the human eye cannot see. This is true even for life-saving medicines. One company was founded to help the industry find these hidden particles and solve a key challenge in the development of complex drug products. Halo Labs’ CEO Rick Gordon spoke with ScienceBoard about how its low volume approach is providing a critical service for the drug development industry. Read More
Investment into regenerative medicine grows alongside company collaborations
Regenerative medicine is a relatively new area of medicine that involves significant research into how to harness the body's own healing mechanisms as treatments for a variety of diseases, including cardiovascular diseases, diabetes, and osteoarthritis. This is performed through the use of stem cell therapies, tissue engineering, and medical devices. The field is rapidly expanding, with many companies forming strategic research partnerships. Read More
Newfound understanding of tissue migration can harness cancer spread
New research has uncovered mechanistic details in living tissue that explain how tissue exercises physical stresses to induce motion in vivo. The study, published in Nature Cell Biology on February 14, documents that the rear end of moving tissue plays a primary role in pushing tissue forward. This finding could be the basis for understanding organ development and the spread of cancer. Read More
Colonic gene mapping provides insights into intestinal diseases
Researchers have used spatial transcriptomics to uncover an unprecedented view of the molecular regionalization of the murine colon. This research, published in Nature Communications on February 11, provides novel insights into inflammatory bowel disease. Read More
IsoPlexis uses proteomics to identify early factors of long COVID
IsoPlexis has published a study in Cell, led by the Institute for Systems Biology and the Seattle COVID Consortium, in which researchers used IsoPlexis' single-cell functional proteomics platform to identify factors that may predict sustained disease after COVID-19 infection, also known as post-acute sequelae of COVID-19 (PASC) or long COVID. Read More
Atlas finds hundreds of genes that control the brain's shape
The shapes of our brains are heavily influenced by our genes, although the precise nature of this complex relationship is difficult to pin down. Now, a study published on February 3 in Science has used a genetics-based atlas of the cerebral cortex to identify hundreds of new gene variants that are linked to growth of specific regions. Read More
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