Drug Discovery & Development
Thermo Fisher Scientific opens cell therapy facility at University of California, San Francisco
Thermo Fisher Scientific and the University of California, San Francisco (UCSF) said Monday that they will develop cell therapies for difficult-to-treat conditions, including cancers, rare diseases, and other illnesses. Read More
RNA-seq analysis links protein to spread of pancreatic cancer, reveals potential drug target
An analysis of 400 pancreatic cancer tumor samples has linked a protein that controls RNA processing to the formation of metastases, suggesting that it may be possible to delay the spread of the cancer. Read More
Clinical investigators need to be wary of confounding and bias in real-world studies; here is what to look for and how to address it
Clinical investigators use real-world data (RWD) in randomized trials and observational studies to produce real-world evidence (RWE) used to assess the safety and efficacy of an intervention and to inform product development, regulatory approval, and post-market surveillance efforts. Read More
HER2-targeting nanoparticles eradicate tumors in mice in ‘hit and run’ attack
A nanoparticle loaded with HER2-targeting antibody fragments and cytotoxic payloads performs a “hit and run” attack on gastric cancers in mice, eradicating the tumors while being safely cleared from the body via the kidneys to minimize toxicity. Read More
Simpler, cheaper screening method developed to democratize COVID-19 drug discovery
An alternative method for finding single-chain antibodies has yielded COVID-19 drug candidates that may be effective against variants of concern. Read More
Enzyme-activated drug candidate points to new way to treat liver cancer
Small molecules that are activated by an enzyme produced by some tumors could improve the treatment of liver cancer, a study run by scientists at the National Institutes of Health (NIH) and Massachusetts General Hospital suggests. Read More
GHIT Fund provides $1.9M for malaria drug development
The Global Health Innovative Technology (GHIT) Fund on Monday announced approximately $1.9 million (260 million yen) in funding for the research and development of a new malaria drug. Read More
Pfizer to acquire Seagen for $43 billion
Pfizer will acquire Seagen, a firm specializing in the discovery and development of treatments for cancer, the firms announced on Monday. Read More
Nasal antibody modulates inflammatory response in COVID-19 patients in small clinical trial
A nasally administered monoclonal antibody modulated inflammatory responses in COVID-19 patients in a small clinical trial. Read More
Light-controlled drug delivery platform opens opportunities to treat pain, cancer
A self-powered, light-controlled drug delivery platform could enable the controlled release of medicines and eliminate the need to surgically extract the implant after use, according to research published in the Proceedings of the National Academy of Sciences (PNAS). Read More
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