CRISPR reveals interconnected map of immune feedback loops, regulatory networks
July 12, 2022 -- The disruption of thousands of genes using CRISPR-Cas9 gene editing has revealed a map of how human immune cells function. The resulting map could reveal the collections of genes that need to function properly to prevent immune diseases. Read More
Study finds cancer cells gravitate toward mechanical ‘sweet spot’ environments
July 12, 2022 -- An international team of researchers, led by University of Minnesota Twin Cities engineers, has discovered that cancer cells invade the body based on the stiffness of their environment, providing a new understanding of how cancer spreads and the potential for improvements to future treatments. Read More
Researchers identify which mice not to use for sickle cell disease studies
July 11, 2022 -- Researchers in Memphis, TN, have learned why certain mice die when testing new gene-based therapies for sickle cell disease and encourage scientists to carefully consider the genetics of the mice they are using to study human diseases. Read More
Researchers develop 'wise counsel' for biological systems
July 11, 2022 -- Researchers at the Max Planck Institute for Terrestrial Microbiology created Machine Learning Guided Experimental Trials for Improvement of Systems, a modular software system for optimizing biological systems. Read More
Single-cell sequencing finds subset of CAR T cells that drive anticancer effects
July 8, 2022 -- A small subset of the CAR T cells prepared for therapy produce most of the anticancer activity, suggesting it may be possible to improve the treatment, according to a study published in the journal Cancer Discovery. Read More
Large DNA insertions in CRISPR-edited cells could increase cancer risk: study
July 7, 2022 -- CRISPR-Cas9 can cause large rearrangements of DNA through retrotransposition to theoretically trigger tumor development, according to a paper published in Nature Communications. Read More
Mini kidneys reveal secrets of tuberous sclerosis complex
July 7, 2022 -- Researchers from Ottawa, Ontario have discovered which cells cause tumors in patients with tuberous sclerosis complex by creating genetically engineered kidney organoids, or “mini kidneys” grown from human tissue. Read More
Plant-microbe biology study uncovers trigger for tumor growth in humans
July 6, 2022 -- Targeting the plasminogen-apple-nematode domain can block cell proliferation, pointing to the potential to treat certain cancers, according to a paper published in the journal Communications Biology. Read More
Scientists able to visualize mRNA molecules in brains of living mice
July 6, 2022 -- A team of researchers has developed a new imaging technique that gives scientists a real-time view into mRNA synthesis and gene expression in the brain of a mouse while it is still alive. Read More
Researchers find how EGFR sends signals into cells, could help cancer drug design
July 6, 2022 -- Chemists at the Massachusetts Institute of Technology have revealed how the epidermal growth factor receptor (EGFR) changes its shape when it binds to its target and how those changes trigger cells to grow and proliferate. Their insights into EGFR could help researchers design new cancer drugs that target this protein. Read More
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