Soluble BCMA acts as decoy receptor to curb blood cancers in mice: study
July 27, 2022 -- A soluble version of B-cell maturation antigen (BCMA), a B-cell surface receptor, may act as a decoy to stop two proteins driving the growth of blood cancers, according to a new study by researchers at Stanford University. Read More
ARM, NIIMBL offer best practices, standards for cell therapy manufacturing challenges
July 26, 2022 -- The Alliance for Regenerative Medicine (ARM) and the National Institute for Innovation in Manufacturing BioPharmaceuticals (NIIMBL) have released best practices and a standard methodology intended to assist the cell-based therapy field with its ongoing manufacturing challenges. Read More
3D imaging reveals picture of T-cell activity to unlock solid tumor opportunity
July 26, 2022 -- Researchers have used imaging and transcriptomics to identify T cells with potent serial killing capacity in a push to expand use of the immunotherapies to solid tumors. Read More
Scientists discover new pathway to treat glioblastoma
July 25, 2022 -- Researchers have developed a biomimetic formulation using nanoparticles for lactate metabolism-based synergistic therapy to fight against the brain cancer glioblastoma multiforme. Read More
Spanish researchers unlock the mystery of multidrug resistance
July 25, 2022 -- A team from the Spanish National Cancer Research Centre has determined that mutations that inactivate the function of a particular gene, FBXW7, reduce the sensitivity to the vast majority of drugs and result in multidrug resistance, according to a study published July 21 in EMBO Molecular Medicine. Read More
Analysis of nanoparticles, cancer cells could aid development of nanoparticle-based drugs
July 22, 2022 -- Researchers have identified biomarkers that predict whether different types of cancer cells will take up specific nanoparticles, potentially helping to overcome some obstacles to the development of nanoparticle-based drugs. Read More
New DNA editing tool could enable more personalized cell therapies
July 21, 2022 -- University of Minnesota, Twin Cities researchers have developed a new tool to predict and customize the rate of a type of DNA editing called site-specific recombination, offering the potential for more personalized cell therapies. Read More
Immunotherapy-KRAS inhibitor combination shows promise for lung cancer treatment
July 21, 2022 -- Immunotherapy plus a KRAS inhibitor drug could be a promising new treatment for certain lung tumors, U.K. researchers found. Read More
Study shows potential of CRISPR-Cas9 tools for synthetic gene control, cellular engineering
July 18, 2022 -- Rice University researchers were able to use deactivated Cas9 (dCas9) proteins to target key segments of the human genome to synthetically trigger the transcription of human genes. Using dCas9 proteins, researchers have revealed important details about human promoters and enhancers. Read More
New stem cell mechanism in mice intestines has potential human application
July 13, 2022 -- Researchers have found a new biophysical mechanism that regulates stem cells in the intestines of mice, which could have implications for potential new treatments for human diseases. Read More
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