The continued challenges of flavivirus serology
Flaviviruses are a genus of positive-sense RNA viruses, largely transmitted by mosquito and tick vectors that cause infections, including yellow fever, dengue, the Zika virus, West Nile virus, Japanese encephalitis, and tick-borne encephalitis. In fighting the emergence of flaviviruses, a well-established gap in our arsenal is the availability of accurate diagnostic data. Read More
Nanopore sensor quickly detects infectious viruses
Scientists have designed a nanopore-based sensor that can detect the presence and infectiousness of a virus in a sample within minutes, according to a new study published in Science Advances on September 22. The new method successfully detected SARS-CoV-2, positioning it as a speedier, less fussy alternative to other tests. Read More
New gene therapy platform shows potential against certain muscle diseases
Scientists have engineered a new family of adeno-associated viruses (AAVs) to deliver therapeutic genes to muscle tissue at 100 to 250 times lower doses than previous AAV vectors, potentially reducing the risk of liver damage and other serious side effects, according to a new study published in Cell on September 9. Read More
Researchers figure out how the immune system sparks cell death
Immunologists have discovered how the innate immune system launches a multifaceted attack against invaders through the use of multiple immune sensors. The work was published in Nature on September 1. Read More
Mirus Bio introduces viral vector manufacturing reagents
Mirus Bio announced an expansion of its TransIT VirusGen platform that is compliant with good manufacturing practices viral vector manufacturing to support cell and gene therapy development, process activities, and commercial production. Read More
Scientists visualize viruses in motion using advanced electron microscopy
Advanced electron microscopy has enabled researchers to visualize how human viruses move in high resolution in a near-native environment. The visualization technique, published in Advanced Materials on July 24, could lead to an improved understanding of the molecular mechanisms of vaccines and therapeutics. Read More
Oncolytic viruses move closer to becoming effective cancer therapies
Scientists are identifying key factors that aid in the effectiveness of oncolytic viruses during the treatment of cancers, which could lead to better immunotherapies and inform clinicians which patients might benefit from the treatment. Findings from a June 22 Nature Communications article point to the clinical relevance and underlying mechanisms of a novel anticancer treatment. Read More
New in vitro models offer effective way to study respiratory viruses
A new accessible and scalable protocol for manufacturing in vitro lung cell models could have applications in the development of new therapies for respiratory viral infections and drug toxicology studies on human lungs. Details about the protocol were published in Stem Cells on June 21. Read More
New AI model could predict viral jumps from animals to humans
A new artificial intelligence (AI)-based computational model called SweetNet aimed at characterizing complex carbohydrates could help predict which viruses are likely to spread from animals to humans. The details of the research were published in Cell Reports on June 15. Read More
How one mammalian DNA polymerase challenges the central dogma of biology
New research demonstrates how an unusual mammalian DNA polymerase can facilitate the conversion of RNA into DNA -- the opposite of normal polymerase function. The data, published in Science Advances on June 11, could challenge the central dogma of molecular biology that states that DNA makes RNA, which in turn makes proteins. Read More
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