Single-cell fetal brain profiling uncovers potential ways to treat pediatric tumors
A multinational team of scientists has used single-cell profiling of freshly isolated human fetal tissue to reveal a reference map of the cell states of the most common malignant childhood brain cancer. Read More
Penn researchers create adrenal gland organoid using stem cells
A research team, led by the University of Pennsylvania's School of Veterinary Medicine, has used stem cells to grow an organoid in a petri dish with the characteristics and functions of a human fetal adrenal gland. Read More
Rapidly generated artificial enzymes inhibit COVID-19 infection in preclinical tests
Artificial enzymes targeting the SARS-CoV-2 genome can inhibit viral infection, pointing to a new way to rapidly develop treatments for emerging biological threats such as COVID-19. Read More
Enzyme shown to restore cell volume after exposure to external stressors
Researchers at the University of Pittsburgh and Carnegie Mellon University have shown that with-no-lysine (WNK) kinases activate a "switch" to restore cell volume after exposure to an external stressor, such as high levels of salt or sugar. Read More
New computational method maps architecture of human tissues in unprecedented detail
Weill Cornell Medicine researchers have developed a new computational method to map the architecture of human tissues in unprecedented detail, with the potential to accelerate studies on organ-scale cellular interactions and enable powerful new diagnostic strategies for an array of diseases. Read More
Programmable RNA-sensing technology enables manipulation of specific cell type
Researchers have developed a programmable RNA-sensing technology that triggers the production of a payload protein when it encounters specific cell types, with potential applications in diagnostics and therapeutics. Read More
Challenge to textbook model of GPCR-mediated signaling opens door to new therapies
University of California, San Diego researchers have challenged the textbook model of how G protein-coupled receptors (GPCRs) mediate signaling in a study that could change how drugs against widely pursued targets are developed, including multiple forms of cancer. Read More
Researchers develop way to observe bacteria in 3D environments such as tissues
Hydrogels have enabled Princeton University researchers to see how bacteria grow in 3D environments, enabling them to make unprecedented observations of bacterial colonies in their natural 3D state. Read More
Healing properties of senescent cells raise questions about anti-aging research
University of California, San Francisco researchers have found some senescent cells help to heal damaged tissues, raising questions about the merits of killing them to address age-related diseases. Read More
RNA-based editing tool enables editing of specific cell types
Duke University researchers have used an RNA-based editing tool to introduce proteins into specific types of cells, which they contend could potentially enable modifying very specific cells and cell functions to manage disease. Read More
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