New 'antibody-decorated nanocrystals' target cancer cells Researchers have bioengineered a metal-organic framework antibody drug delivery system that has the potential to fast-track personalized therapies for cancer and other diseases. The findings were published December 7 in the journal Advanced Materials.Read More
Scientists identify diagnostic gene signature for breast cancer Researchers have identified a diagnostic signature for genetic mutations and other abnormalities associated with drug resistance and poor outcomes in estrogen receptor-positive metastatic breast cancers. The findings, published on October 28 in Cancer Research, may one day guide personalized treatments for cancer patients.Read More
New algorithm enables comparisons of tumors across patients Researchers have developed an algorithm that can take either single-cell mass cytometry data or RNA sequencing data, align it, and extract a common denominator for comparing cancer data among patients. The algorithm, called tuMap, was detailed in a study published on October 7 in Cell Systems.Read More
'Minibrains' grown from stem cells replicate brain's electrical activity Researchers have grown 3D human brain tissue from stem cells that replicates the patterns of electrical activity found in the brains of patients with Rett syndrome. These "minibrain organoids" can be used to investigate the underlying causes of neurological disease and screen and test potential drug candidates, according to research published on August 23 in Nature Neuroscience.Read More
Researchers create 3D tumor models with cells from patients Using tissue samples from cancer patients, Israeli researchers have successfully printed an active, viable glioblastoma 3D tumor model. In addition to potential applications in personalized medicine, the achievement promises to speed drug development and increase the chances that developed drugs will succeed in clinical trials. The results were published August 18 in Science Advances.Read More
Machine learning identifies genes important for cancer growth Using machine learning, researchers have developed a method that evaluates the contributions of all possible tumor mutations to the development and progression of cancer. The results of the study were published in Nature on July 28.Read More
Google Cloud launches Healthcare Data Engine Google Cloud announced the preview of Healthcare Data Engine, a tool for healthcare and life sciences organizations that integrates and standardizes data from multiple silos, including medical records, claims, clinical trials, and research data.Read More
Swiss health data network fuels personalized medicine with data-sharing model A nationwide data network has been built in Switzerland to support the exchange and reuse of health-related data produced in biomedical and clinical research settings. The strategy, which could serve as a model for how other countries can accelerate the development of personalized medicine, was recently described in an article in JMIR Medical Informatics.Read More