A*STAR partners with startup to create diabetes cell therapies tailored to Asian patients
BetaLife has acquired the rights to human induced pluripotent stem cell (iPSC) technology from Singapore’s Agency for Science, Technology, and Research (A*STAR) for use in the treatment of diabetes. Read More
Stem cell-loaded plug improves outcomes in hard-to-treat Crohn’s disease patients
Most Crohn’s disease patients experienced complete clinical healing of perianal fistulas after treatment with a stem cell-loaded plug, according to data published in the journal Diseases of the Colon & Rectum. Read More
At SLAS 2023, companies showcase, launch advanced automation and screening technologies
At the Society for Laboratory Automation and Screening (SLAS) 2023 International Conference and Exhibition, being held in San Diego from February 25 to March 1, numerous firms have announced that they are showcasing emerging technologies for advanced life science applications. Read More
Adaptive Biotechnologies Q4 revenues rise 46% on NGS test volumes
Adaptive Biotechnologies on Tuesday reported fourth-quarter revenue of $55.2 million, up 46% compared with $37.9 million in Q4 2021. Read More
Challenges and remedies for manufacturing cell therapies at scale
Cell therapies have the potential to cure human diseases rather than just treat the symptoms, and they are potentially life-changing if they can be administered early in a patient’s lifetime. Read More
Aston University partners with longevity biotech to advance lung disease treatment
Aston University's work on small molecule inhibitors of transglutaminase 2 has spawned a biotech firm focused on treating the chronic lung disease idiopathic pulmonary fibrosis. Read More
T-cell therapy fights viral infections following stem cell transplants
Baylor College of Medicine and Washington University School of Medicine researchers studied posoleucel, an investigational off-the-shelf T-cell therapy that simultaneously targets six different viruses. The results, published January 11 in the journal Clinical Cancer Research, showed promising antiviral efficacy and safety in a phase II clinical trial of patients who had undergone stem cell transplantation to treat blood diseases including cancer. Read More
Optimizing AAV vectors for gene therapy delivery
Adeno-associated viruses (AAV) can be engineered to deliver DNA to target cells. It is used extensively for the development of viral vector-based gene therapies in the pipeline. However, researchers encounter challenges with producing sufficient quantities of AAVs for gene therapy products, and they struggle to get delivery vehicles and their genetic payloads into the brain across the blood-brain barrier. Read More
Demand for viral vectors seen outpacing capacity growth despite investment surge
The growth in demand for viral vectors is outpacing a push to add capacity, leading to predictions that the current supply shortage will continue despite investment in the space. Read More
New type of CAR T cells provide on-off switch to improve cell therapy safety, efficiency
Researchers at Boston University have created on and off switches for chimeric antigen receptor (CAR) T cells, enabling them to control the activity of therapies using an approved drug. Read More
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