Cancer & Disease Research
With Hitachi deal done, Fujifilm sets sights on healthcare growth
Fresh off its acquisition of Hitachi's medical imaging business, Japanese industrial giant Fujifilm on July 1 rebranded its healthcare subsidiaries in the U.S. and Europe to reflect the newly integrated company. The deal exemplifies Fujifilm's plan to make healthcare its primary business. Read More
Algorithm expands what scientists can uncover from individual cells
A new software tool can help researchers further utilize single-cell RNA sequencing data to learn more about individual cells by incorporating biologically relevant data into the analysis. The machine-learning algorithm, detailed in Genome Research on June 30, can be used to predict which transcription factors are most active in individual cells. Read More
Oncolytic viruses move closer to becoming effective cancer therapies
Scientists are identifying key factors that aid in the effectiveness of oncolytic viruses during the treatment of cancers, which could lead to better immunotherapies and inform clinicians which patients might benefit from the treatment. Findings from a June 22 Nature Communications article point to the clinical relevance and underlying mechanisms of a novel anticancer treatment. Read More
What makes immunotherapies successful in one tumor but not in others?
Researchers have developed a new framework to uncover pathophysiological and molecular features that determine the effectiveness of immunotherapies. The research, published in Nature Communications on June 29, provides an opportunity for improving patient care and gaining a deeper understanding of cancer immunotherapy mechanisms. Read More
CAR-NK cells hold promise for solid tumors
A new cancer immunotherapy that leverages the ability of natural killer (NK) cells to discriminate between cancer and normal cells has shown promise in solid tumors. The technology incorporates the cancer-targeting ability of chimeric antigen receptors (CARs), according to data published in iScience on June 25. Read More
Intellia, Regeneron highlight clinical results for CRISPR-Cas9 gene therapy
Intellia Therapeutics and Regeneron Pharmaceuticals have announced positive interim data from an ongoing phase I study of their in vivo candidate, NTLA-2001, as a single-dose treatment for transthyretin amyloidosis. The interim results support the clinical efficacy and safety of in vivo CRISPR genome editing therapy in humans. Read More
How being an effective mentor can advance science
Mentorship in the sciences is about making sure the next generation has the skills needed to be successful and to take science to the next level, explained Michael Howell, PhD, chief scientific officer at DermTech, during a recent conversation with ScienceBoard.net. Read More
FDA issues EUA for monoclonal antibody for treatment of hospitalized COVID-19 patients
The U.S. Food and Drug Administration (FDA) has issued an emergency use authorization (EUA) to Genentech, a member of the Roche Group, for tocilizumab (Actemra) for the treatment of hospitalized adults and pediatric patients. Read More
Advancing from CAR T-cell therapies to modified NK cell therapies
Chimeric antigen receptor (CAR) T-cell therapies have quickly become promising candidates for the treatment of many cancers. However, other immune cell types, such as natural killer (NK) cells, may be effective for some cancers, such as solid tumors, that are traditionally challenging for CAR T therapies. The science behind this concept is worth examining. Read More
Do mom's or dad's genes win out in a child's gene expression?
A team of scientists has identified 71 new "imprinted" genes in the mouse genome. The new findings, published in Nature Communications on June 21, help uncover some of the scientific mysteries associated with epigenetics and point to how a parent's genes are uniquely turned off or on in their offspring. Read More
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